反应详情

89 g (0.581 mole) 2-Aza-spiro[4,5]decan-3-one are stirred under reflux for 4 hours with semiconcentrated hydrochloric acid. The reaction mixture is cooled to ambient temperature, diluted with water and extracted with methylene chloride for the removal of the starting material. The aqueous phase is evaporated to dryness in a vacuum and the residue obtained is mixed with acetone. Upon standing, 79.85 g, 1-aminomethyl-1-cyclohexaneacetic acid hydrochloride (64.7% of theory) crystallize out; content 99%; m.p. 123° to 127° C.

1. extractionextracted with methylene chloride for the removal of the starting material
2. customThe aqueous phase is evaporated to dryness in a vacuum
3. customthe residue obtained
4. custom79.85 g, 1-aminomethyl-1-cyclohexaneacetic acid hydrochloride (64.7% of theory) crystallize out