Acetic Acid → tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate

HRID 153504Notes

Reaction equation

HRID 153504 reaction equation
[CH3:23][C:24](=[O:25])[OH:26].[CH3:27][OH:28].[Fe:29].[N+:1]([O-:2])(=[O:3])[c:4]1[cH:5][cH:6][c:7]([N:10]2[CH2:11][CH2:12][N:13]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:14][CH2:15]2)[n:8][cH:9]1>>[NH2:1][c:4]1[cH:5][cH:6][c:7]([N:10]2[CH2:11][CH2:12][N:13]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:14][CH2:15]2)[n:8][cH:9]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 887MethanolHCID 23925IronHCID 16217943tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate

Product 1

HCID 17999304tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-9f363e1bd5184053a0478c1582515848
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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