(5-Methoxy-1-benzofuran-2-yl)methanol → 2-Benzofurancarboxaldehyde, 5-methoxy-

HRID 1535049Notes

Reaction equation

HRID 1535049 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([CH2:11][OH:12])=[CH:8][C:7]=2[CH:13]=1>O=[Mn]=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([CH:11]=[O:12])=[CH:8][C:7]=2[CH:13]=1

Participants

3

Reactant 1

HCID 15161064(5-Methoxy-1-benzofuran-2-yl)methanol

Product 1

HCID 316632-Benzofurancarboxaldehyde, 5-methoxy-Yield 60%

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Procedure

To a solution of 5-methoxy-2-hydroxymethylbenzofuran (16.0 gm; 90 mmoles) in ethyl acetatel (1 L) was added MnO2 (78 gm, 900 mmoles). The reaction mixture was stirred at room temperature for 3 hours. Then this suspension was filtered through celite and concentrate in vacuo. The filtrate yielded the title Compound E9, (9.5 gm, 60%).

Workup

  1. filtrationThen this suspension was filtered through celite
  2. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-69234d5c0ede43d9b79317bf3c16241d
Source dataset
uspto-grants-1992_02
Patent number
US05091533

Reaction notes

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