反应详情

A mixture of 2-hydroxy-5-benzyloxyacetophenone (93 g, 380 mmoles), p-methoxyphenacyl bromide (88 g, 384 mmoles) and potassium carbonate (106 g, 768 mmoles) in acetone (1.5 L) was refluxed for 46 hours. The reaction mixture was cooled and filtered. The filtrate was evaporated in vacuo. The residue was chromatographed on silica gel using 10% ethylacetate in hexane as eluent to yield (127 g, 89%) of 2-(p-methoxybenzyl)-3-methyl-5-benzyloxybenzofuran, E48.

1. temperaturewas refluxed for 46 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. customThe filtrate was evaporated in vacuo
5. customThe residue was chromatographed on silica gel using 10% ethylacetate in hexane as eluent