Hydrochloric Acid → 3-(2-Chlorophenyl)-5-hydroxymethyl-1-phenyl-1,2-dihydropyridin-2-one

HRID 1535684Notes

Reaction equation

HRID 1535684 reaction equation
[Br:25][c:26]1[c:27](=[O:28])[n:29](-[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[cH:36][c:37]([C:38]([O:39][CH3:40])=[O:41])[cH:42]1.[C:64](=[O:65])([O-:66])[OH:67].[CH2:54]([Al+:55][CH2:56][CH:57]([CH3:58])[CH3:59])[CH:60]([CH3:61])[CH3:62].[CH3:69][c:70]1[cH:71][cH:72][cH:73][cH:74][cH:75]1.[Cl:1][c:2]1[c:3](-[c:8]2[c:9](=[O:24])[n:10](-[c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[cH:11][c:12]([C:14](=[O:15])[O:16][CH3:17])[cH:13]2)[cH:4][cH:5][cH:6][cH:7]1.[Cl:43][c:44]1[cH:45][cH:46][cH:47][cH:48][c:49]1[B:50]([OH:51])[OH:52].[ClH:63].[H-:53].[Na+:68]>>[Cl:1][c:2]1[c:3](-[c:8]2[c:9](=[O:24])[n:10](-[c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[cH:11][c:12]([CH2:14][OH:15])[cH:13]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 1140TolueneHCID 166653HydrideHCID 27343222-Chlorophenylboronic acidHCID 16686348Bis(2-methylpropyl)alumanyliumHCID 223189503-Bromo-5-methoxycarbonyl-1-phenyl-1,2-dihydropyridin-2-oneHCID 223190963-(2-Chlorophenyl)-5-methoxycarbonyl-1-phenyl-1,2-dihydropyridin-2-one

Product 1

HCID 223189533-(2-Chlorophenyl)-5-hydroxymethyl-1-phenyl-1,2-dihydropyridin-2-one

Sources & evidence

ORD record
ord-8273613f951d4ff290d3092177d20560
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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