Pyridine → 1-[2-Fluoro-4-(2-phenoxycarbonylaminopyridin-4-yloxy)phenylcarbamoyl]cyclopropanecarboxylic acid benzyl ester

HRID 1536799Notes

Reaction equation

HRID 1536799 reaction equation
[CH2:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[O:16][C:17](=[O:18])[C:19]1([C:22]([NH:23][c:24]2[c:25]([F:38])[cH:26][c:27]([O:30][c:31]3[cH:32][c:33]([NH2:37])[n:34][cH:35][cH:36]3)[cH:28][cH:29]2)=[O:39])[CH2:20][CH2:21]1.[CH3:6][C:7]#[N:8].[Cl:40][C:41](=[O:42])[O:43][c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1.[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1.[cH:50]1[cH:51][cH:52][n:53][cH:54][cH:55]1>>[CH2:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[O:16][C:17](=[O:18])[C:19]1([C:22]([NH:23][c:24]2[c:25]([F:38])[cH:26][c:27]([O:30][c:31]3[cH:32][c:33]([NH:37][C:41](=[O:42])[O:43][c:44]4[cH:45][cH:46][cH:47][cH:48][cH:49]4)[n:34][cH:35][cH:36]3)[cH:28][cH:29]2)=[O:39])[CH2:20][CH2:21]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 6342AcetonitrileHCID 8028TetrahydrofuranHCID 15891Phenyl chloroformateHCID 59459707HCID 59459707, compound

Product 1

HCID 247886951-[2-Fluoro-4-(2-phenoxycarbonylaminopyridin-4-yloxy)phenylcarbamoyl]cyclopropanecarboxylic acid benzyl ester

Sources & evidence

ORD record
ord-d1bec17026b24ee9ae4fe5dee2e8bc07
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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