Phosphate → Tert-butyl 2-[2-benzyl-1-hydroxy-3-oxo-3-(2-oxo-4-propan-2-yl-1,3-oxazolidin-3-yl)propyl]-4-fluoropyrrolidine-1-carboxylate

HRID 1537841Notes

Reaction equation

HRID 1537841 reaction equation
[C:46]([CH3:47])([CH3:48])([CH3:49])[O:50][C:51](=[O:52])[N:53]1[CH:54]([CH:59]=[O:60])[CH2:55][CH:56]([F:58])[CH2:57]1.[CH2:9]([B+:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:15][CH2:16][CH3:17].[CH:18]([CH3:19])([CH3:20])[CH:21]1[N:22]([C:27]([CH2:28][CH2:29][c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)=[O:36])[C:23](=[O:26])[O:24][CH2:25]1.[CH:37]([N:38]([CH2:39][CH3:40])[CH:41]([CH3:42])[CH3:43])([CH3:44])[CH3:45].[Cl:66][CH2:67][Cl:68].[O-:61][P:62](=[O:63])([O-:64])[O-:65].[S:1]([O-:2])([C:3]([F:4])([F:5])[F:6])(=[O:7])=[O:8]>>[CH:18]([CH3:19])([CH3:20])[CH:21]1[N:22]([C:27]([CH:28]([CH2:29][c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[CH:59]([CH:54]2[N:53]([C:51]([O:50][C:46]([CH3:47])([CH3:48])[CH3:49])=[O:52])[CH2:57][CH:56]([F:58])[CH2:55]2)[OH:60])=[O:36])[C:23](=[O:26])[O:24][CH2:25]1

Participants

8

Reactant 7

HCID 1061PhosphateHCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 2758875TrifluoromethanesulfonateHCID 134617423-(3-Phenylpropanoyl)-4-propan-2-yl-1,3-oxazolidin-2-oneHCID 56973582Tert-butyl 4-fluoro-2-formylpyrrolidine-1-carboxylateHCID 178440531HCID 178440531, compound

Product 1

HCID 68814725Tert-butyl 2-[2-benzyl-1-hydroxy-3-oxo-3-(2-oxo-4-propan-2-yl-1,3-oxazolidin-3-yl)propyl]-4-fluoropyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-c5fea97d74a84a5ba57b4636227690db
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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