Tetrahydrofuran → 2-Bromo-6-chloro-4-methylpyridine

HRID 1537980Notes

Reaction equation

HRID 1537980 reaction equation
[C:20]([Br:21])([Br:22])([Br:23])[Br:24].[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH2:9]([Li:10])[CH2:11][CH2:12][CH3:13].[CH3:14][N:15]([CH:16]([OH:17])[CH3:18])[CH3:19].[CH3:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([CH3:8])[cH:7]1>>[Cl:1][c:2]1[n:3][c:4]([Br:21])[cH:5][c:6]([CH3:8])[cH:7]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8058HexaneHCID 11205Carbon tetrabromideHCID 772482-Chloro-4-methylpyridineHCID 10313070Dimethylamino-ethanolHCID 178418339Butyllithium

Product 1

HCID 111172342-Bromo-6-chloro-4-methylpyridine

Sources & evidence

ORD record
ord-8bdd7ca06874452e94eeeb9ff594ee8e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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