p-Toluenesulfonic acid → 4-methylbenzenesulfonate;methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate

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Reaction Steps

Clopidogrel base was dissolved in acetone to obtain a clear solution. To it was added p-toluene sulfonic acid at room temperature. The reaction mixture was heated to reflux temperature for 2 to 10 hrs. The solvent was evaporated to dryness under reduced pressure to obtain amorphous Clopidogrel tosylate.

Provenance & Evidence