反应详情

Clopidogrel base was dissolved in acetone to obtain a clear solution. To it was added p-toluene sulfonic acid at room temperature. The reaction mixture was heated to reflux temperature for 2 to 10 hrs. The solvent was evaporated to dryness under reduced pressure to obtain amorphous Clopidogrel tosylate.

1. customto obtain a clear solution
2. temperatureThe reaction mixture was heated
3. temperatureto reflux temperature for 2 to 10 hrs
4. customThe solvent was evaporated to dryness under reduced pressure