Dichloromethane → 2-{4-[1-(3-Fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxymethyl}-morpholine-4-carboxylic acid tert-butyl ester
Reaction equation
[C:34]([CH3:35])([CH3:36])([CH3:37])[O:38][C:39](=[O:40])[N:41]1[CH2:42][CH:43]([CH2:47][OH:48])[O:44][CH2:45][CH2:46]1.[CH:49]([N:50]([CH2:51][CH3:52])[CH:53]([CH3:54])[CH3:55])([CH3:56])[CH3:57].[Cl:58][CH2:59][Cl:60].[F:5][c:6]1[cH:7][c:8]([CH2:9][n:10]2[n:11][cH:12][c:13]3[cH:14][c:15]([NH:19][c:20]4[n:21][cH:22][n:23][n:24]5[c:25]4[c:26]([CH2:29][OH:30])[cH:27][cH:28]5)[cH:16][cH:17][c:18]23)[cH:31][cH:32][cH:33]1.[S:1]([Cl:2])([Cl:3])=[O:4]>>[F:5][c:6]1[cH:7][c:8]([CH2:9][n:10]2[n:11][cH:12][c:13]3[cH:14][c:15]([NH:19][c:20]4[n:21][cH:22][n:23][n:24]5[c:25]4[c:26]([CH2:29][O:30][CH2:47][CH:43]4[CH2:42][N:41]([C:39]([O:38][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:40])[CH2:46][CH2:45][O:44]4)[cH:27][cH:28]5)[cH:16][cH:17][c:18]23)[cH:31][cH:32][cH:33]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-4df8f0ab1daf46b08ca87be896bf14fc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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