Tetrahydrofuran → 3-[4-Chloro-2-(2-fluoro-alpha-hydroxy-benzyl)-phenyl]-4-hydroxymethyl-2-methyl-pyrazole

HRID 1538255Notes

Reaction equation

HRID 1538255 reaction equation
[Al+3:2].[Cl:5][c:6]1[cH:7][c:8]2[c:9]([cH:27][cH:28]1)-[c:10]1[c:11]([cH:23][n:24][n:25]1[CH3:26])[C:12](=[O:22])[O:13][CH:14]2[c:15]1[c:16]([F:21])[cH:17][cH:18][cH:19][cH:20]1.[H-:1].[H-:3].[H-:4].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[Cl:5][c:6]1[cH:7][c:8]([CH:14]([OH:13])[c:15]2[c:16]([F:21])[cH:17][cH:18][cH:19][cH:20]2)[c:9](-[c:10]2[c:11]([CH2:12][OH:22])[cH:23][n:24][n:25]2[CH3:26])[cH:27][cH:28]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 104727Aluminum CationHCID 166653Hydride3×HCID 203215648-chloro-6-(2-fluoro-phenyl)-1-methyl-4-oxo-1H,6H-pyrazolo[4,3-d](2)benzoxepine

Product 1

HCID 203215663-[4-Chloro-2-(2-fluoro-alpha-hydroxy-benzyl)-phenyl]-4-hydroxymethyl-2-methyl-pyrazole

Sources & evidence

ORD record
ord-2d4387c4d1a04c24bf8c7b8c9056a6f2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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