Dichloromethane → 2-Phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

HRID 1538569Notes

Reaction equation

HRID 1538569 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][cH:16][c:17]([NH:20][C:21](=[O:22])[c:23]3[n:24][c:25](-[c:32]4[cH:33][cH:34][cH:35][cH:36][cH:37]4)[o:26][c:27]3[C:28]([F:29])([F:30])[F:31])[cH:18][cH:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:45][CH2:46][Cl:47].[OH:38][C:39]([C:40]([F:41])([F:42])[F:43])=[O:44]>>[NH:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][cH:16][c:17]([NH:20][C:21](=[O:22])[c:23]3[n:24][c:25](-[c:32]4[cH:33][cH:34][cH:35][cH:36][cH:37]4)[o:26][c:27]3[C:28]([F:29])([F:30])[F:31])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 667383654-{4-[(2-Phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 529371572-Phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

Sources & evidence

ORD record
ord-89ba2d8934c04dc4988ad3b7fe91f0a1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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