Methanol → 6-chloro-4'-[5-chloro-2-(1-ethyl-1-hydroxycarbonyl-propoxy)-phenyl]-2'-(5-chloro-2-methyl-phenyl) spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione
Reaction equation
[CH3:46][OH:47].[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:33][C:34]([CH2:35][CH3:36])([C:37](=[O:38])[O:39][CH3:40])[CH2:41][CH3:42])[c:6]([CH:8]2[CH2:9][C:10](=[O:32])[NH:11][CH:12]([c:24]3[c:25]([CH3:31])[cH:26][cH:27][c:28]([Cl:30])[cH:29]3)[C:13]23[C:14](=[O:23])[NH:15][c:16]2[cH:17][c:18]([Cl:22])[cH:19][cH:20][c:21]23)[cH:7]1.[Li+:44].[OH-:43].[OH2:45]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:33][C:34]([CH2:35][CH3:36])([C:37](=[O:38])[OH:39])[CH2:41][CH3:42])[c:6]([CH:8]2[CH2:9][C:10](=[O:32])[NH:11][CH:12]([c:24]3[c:25]([CH3:31])[cH:26][cH:27][c:28]([Cl:30])[cH:29]3)[C:13]23[C:14](=[O:23])[NH:15][c:16]2[cH:17][c:18]([Cl:22])[cH:19][cH:20][c:21]23)[cH:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-ff31f4b014554d79b8b30d1060664755
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
Loading…