Dichloromethane → 4-{2-[(Morpholine-4-carbonyl)-amino]-2-phenyl-acetyl}-morpholine-3-carboxylic acid {4-[3-(5-chloro-2-hydroxy-phenyl)-1-methyl-1H-pyrazol-4-ylethynyl]-phenyl}-amide
Reaction equation
[CH3:51][CH2:52][N:53]([CH2:54][CH3:55])[CH2:56][CH3:57].[Cl:1][c:2]1[cH:3][cH:4][c:5]([OH:41])[c:6](-[c:8]2[n:9][n:10]([CH3:40])[cH:11][c:12]2[C:13]#[C:14][c:15]2[cH:16][cH:17][c:18]([NH:21][C:22](=[O:23])[CH:24]3[CH2:25][O:26][CH2:27][CH2:28][N:29]3[C:30]([CH:31]([c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[NH2:38])=[O:39])[cH:19][cH:20]2)[cH:7]1.[Cl:58][CH2:59][Cl:60].[O:42]1[CH2:43][CH2:44][N:45]([C:48](=[O:49])[Cl:50])[CH2:46][CH2:47]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([OH:41])[c:6](-[c:8]2[n:9][n:10]([CH3:40])[cH:11][c:12]2[C:13]#[C:14][c:15]2[cH:16][cH:17][c:18]([NH:21][C:22](=[O:23])[CH:24]3[CH2:25][O:26][CH2:27][CH2:28][N:29]3[C:30]([CH:31]([c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[NH:38][C:48]([N:45]3[CH2:44][CH2:43][O:42][CH2:47][CH2:46]3)=[O:49])=[O:39])[cH:19][cH:20]2)[cH:7]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-e70e8ae1617447daa108357f00d548d2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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