Dichloromethane → N-(4-bromo-2,6-difluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine

HRID 1539454Notes

Reaction equation

HRID 1539454 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:37])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:20][CH:21]4[CH2:22][CH2:23][N:24]([C:27]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33])[CH2:25][CH2:26]4)[c:14]([O:17][CH3:18])[cH:15][c:16]23)[c:34]([F:36])[cH:35]1.[CH2:45]([Cl:46])[Cl:47].[F:38][C:39]([F:40])([F:41])[C:42]([OH:43])=[O:44]>>[Br:1][c:2]1[cH:3][c:4]([F:37])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:20][CH:21]4[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]4)[c:14]([O:17][CH3:18])[cH:15][c:16]23)[c:34]([F:36])[cH:35]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 109738974-(4-Bromo-2,6-difluoroanilino)-7-(1-(tert-butoxycarbonyl)piperidin-4-ylmethoxy)-6-methoxyquinazoline

Product 1

HCID 5329051N-(4-bromo-2,6-difluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine

Sources & evidence

ORD record
ord-829efaf45caf40a893c550f38b4d7c01
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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