Toluene → 8-cyclopentyl-6-(1-ethoxy-vinyl)-5-methyl-2-[5-(4-methyl-piperazin-1-yl)-pyridin-2-ylamino]-8H-pyrido[2,3-d]pyrimidin-7-one
Reaction equation
[Br:1][c:2]1[c:3]([CH3:32])[c:4]2[c:5]([n:6][c:7]([NH:10][c:11]3[n:12][cH:13][c:14]([N:17]4[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]4)[cH:15][cH:16]3)[n:8][cH:9]2)[n:24]([CH:27]2[CH2:28][CH2:29][CH2:30][CH2:31]2)[c:25]1=[O:26].[CH2:40]([Sn:41]([CH2:42][CH2:43][CH2:44][CH3:50])([C:45](=[CH2:46])[O:47][CH2:48][CH3:49])[CH2:51][CH2:52][CH2:53][CH3:54])[CH2:55][CH2:56][CH3:57].[CH3:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[CH:58]([Cl:59])([Cl:60])[Cl:61].[Pd:62].[c:101]1([P:102]([c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)[c:109]2[cH:110][cH:111][cH:112][cH:113][cH:114]2)[cH:115][cH:116][cH:117][cH:118][cH:119]1.[c:120]1([P:121]([c:122]2[cH:123][cH:124][cH:125][cH:126][cH:127]2)[c:128]2[cH:129][cH:130][cH:131][cH:132][cH:133]2)[cH:134][cH:135][cH:136][cH:137][cH:138]1.[c:63]1([P:64]([c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[cH:77][cH:78][cH:79][cH:80][cH:81]1.[c:82]1([P:83]([c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)[c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)[cH:96][cH:97][cH:98][cH:99][cH:100]1>>[c:2]1([C:45](=[CH2:46])[O:47][CH2:48][CH3:49])[c:3]([CH3:32])[c:4]2[c:5]([n:6][c:7]([NH:10][c:11]3[n:12][cH:13][c:14]([N:17]4[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]4)[cH:15][cH:16]3)[n:8][cH:9]2)[n:24]([CH:27]2[CH2:28][CH2:29][CH2:30][CH2:31]2)[c:25]1=[O:26]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-eecafcbc5d464fef949522311268e952
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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