Dichloromethane → [2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanone

HRID 1539746Notes

Reaction equation

HRID 1539746 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[n:16][c:17]([NH2:30])[c:18]([C:21]([c:22]3[c:23]([F:28])[cH:24][cH:25][cH:26][cH:27]3)=[O:29])[cH:19][cH:20]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:38][CH2:39][Cl:40].[OH:31][C:32]([C:33]([F:34])([F:35])[F:36])=[O:37]>>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[n:16][c:17]([NH2:30])[c:18]([C:21]([c:22]3[c:23]([F:28])[cH:24][cH:25][cH:26][cH:27]3)=[O:29])[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 585908374-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 58590835[2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanone

Sources & evidence

ORD record
ord-c0f7f5025334435cbaacc2ca37188bb4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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