反应详情

The effect of the amount of TFA acid catalyst was evaluated. (S)-1-Allyl-3-benzyl-6-methylenepiperazine-2,5-dione was prepared by reacting N-2-oxo-propanoyl-L-phenylalanine allylamide with various amounts of trifluoroacetic acid for 24 hours. Enantiomeric excess of the product was determined by chiral HPLC using a CHIRALCEL OD column eluted with n-Hexane:Ethanol (5:1). The TFA amounts, product yields, and enantiometric excess presented in Table 2.

1. customfor 24 hours
2. washeluted with n-Hexane:Ethanol (5:1)
3. customproduct yields