Dichloromethane → Methyl 2-amino-5-[5-[[2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl]-methylamino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]pent-4-ynoate
Reaction equation
[Cl:59][CH2:60][Cl:61].[F:1][C:2]([c:3]1[cH:4][c:5]([C:13]([C:14](=[O:15])[N:16]([c:17]2[c:18](-[c:39]3[c:40]([CH3:46])[cH:41][c:42]([F:45])[cH:43][cH:44]3)[cH:19][c:20]([C:23]#[C:24][CH2:25][CH:26]([C:27](=[O:28])[O:29][CH3:30])[NH:31][C:32]([O:33][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[n:21][cH:22]2)[CH3:47])([CH3:48])[CH3:49])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:50])[F:51].[F:52][C:53]([F:54])([F:55])[C:56]([OH:57])=[O:58]>>[F:1][C:2]([c:3]1[cH:4][c:5]([C:13]([C:14](=[O:15])[N:16]([c:17]2[c:18](-[c:39]3[c:40]([CH3:46])[cH:41][c:42]([F:45])[cH:43][cH:44]3)[cH:19][c:20]([C:23]#[C:24][CH2:25][CH:26]([C:27](=[O:28])[O:29][CH3:30])[NH2:31])[n:21][cH:22]2)[CH3:47])([CH3:48])[CH3:49])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:50])[F:51]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-e0737047c60d4ee7b0238f865c566af0
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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