Dichloromethane → 4-(azetidin-3-yloxy)-5-bromo-N-(cis-4-methylcyclohexyl)pyrimidin-2-amine
Reaction equation
[Br:1][c:2]1[c:3]([O:16][CH:17]2[CH2:18][N:19]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:20]2)[n:4][c:5]([NH:8][CH:9]2[CH2:10][CH2:11][CH:12]([CH3:15])[CH2:13][CH2:14]2)[n:6][cH:7]1.[Cl:35][CH2:36][Cl:37].[F:28][C:29]([F:30])([F:31])[C:32]([OH:33])=[O:34]>>[Br:1][c:2]1[c:3]([O:16][CH:17]2[CH2:18][NH:19][CH2:20]2)[n:4][c:5]([NH:8][CH:9]2[CH2:10][CH2:11][CH:12]([CH3:15])[CH2:13][CH2:14]2)[n:6][cH:7]1Participants
4
Sources & evidence
- ORD record
- ord-f95f897f566c40d9b8393327d5c0adc0
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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