Dimethylformamide → 2-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid [5-fluoro-3-(3-hydroxy-3-methyl-butyl)-indol-1-yl]-amide

HRID 1541706Notes

Reaction equation

HRID 1541706 reaction equation
[F:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][cH:10][c:11]([C:15](=[O:16])[OH:17])[c:12]([CH3:14])[n:13]2)[cH:5][cH:6][cH:7]1.[NH2:18][n:19]1[cH:20][c:21]([CH2:29][CH2:30][C:31]([CH3:32])([OH:33])[CH3:34])[c:22]2[cH:23][c:24]([F:28])[cH:25][cH:26][c:27]12.[O:35]=[CH:36][N:37]([CH3:38])[CH3:39]>>[F:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][cH:10][c:11]([C:15](=[O:17])[NH:18][n:19]3[cH:20][c:21]([CH2:29][CH2:30][C:31]([CH3:32])([OH:33])[CH3:34])[c:22]4[cH:23][c:24]([F:28])[cH:25][cH:26][c:27]34)[c:12]([CH3:14])[n:13]2)[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 617025872-(3-Fluorophenyl)-4-methylpyrimidine-5-carboxylic acidHCID 685521584-(1-amino-5-fluoro-1H-indol-3-yl)-2-methyl-butan-2-ol

Product 1

HCID 591999452-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid [5-fluoro-3-(3-hydroxy-3-methyl-butyl)-indol-1-yl]-amide

Sources & evidence

ORD record
ord-5aeb72c8da3c4c5cb7b5c9ed604bde96
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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