Dichloromethane → N-(3,3-difluoropiperidin-4-yl)-8-(2,3,4-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

HRID 1542065Notes

Reaction equation

HRID 1542065 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][C:10]([F:33])([F:34])[CH:11]([NH:14][c:15]2[n:16][n:17]3[c:18]([c:19](-[c:23]4[c:24]([F:31])[c:25]([F:30])[c:26]([F:29])[cH:27][cH:28]4)[cH:20][cH:21][cH:22]3)[n:32]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:42][CH2:43][Cl:44].[F:35][C:36]([F:37])([F:38])[C:39]([OH:40])=[O:41]>>[NH:8]1[CH2:9][C:10]([F:33])([F:34])[CH:11]([NH:14][c:15]2[n:16][n:17]3[c:18]([c:19](-[c:23]4[c:24]([F:31])[c:25]([F:30])[c:26]([F:29])[cH:27][cH:28]4)[cH:20][cH:21][cH:22]3)[n:32]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 673428633,3-Difluoro-4-[8-(2,3,4-trifluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 67343436N-(3,3-difluoropiperidin-4-yl)-8-(2,3,4-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Sources & evidence

ORD record
ord-e294e556198245da9ede7e7a19abaaa8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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