Citric Acid → 1-tert-Butyl 3-methyl 2,3-dihydropyridine-1,3(6H)-dicarboxylate

HRID 1542070Notes

Reaction equation

HRID 1542070 reaction equation
[C:13]([CH3:14])([CH3:15])([CH3:16])[O:17][C:18](=[O:19])[N:20]1[CH2:21][CH:22]([C:26](=[O:27])[OH:28])[CH:23]=[CH:24][CH2:25]1.[C:1]([n:2]1[cH:3][cH:4][n:5][cH:6]1)([n:7]1[cH:8][cH:9][n:10][cH:11]1)=[O:12].[CH2:44]([Cl:45])[Cl:46].[CH3:29][OH:30].[OH:31][C:32]([CH2:33][C:34]([C:35](=[O:36])[OH:37])([CH2:38][C:39](=[O:40])[OH:41])[OH:42])=[O:43]>>[CH3:1][O:28][C:26]([CH:22]1[CH2:21][N:20]([C:18]([O:17][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:19])[CH2:25][CH:24]=[CH:23]1)=[O:27]

Participants

6

Reactant 5

HCID 311Citric AcidHCID 887MethanolHCID 6344DichloromethaneHCID 682631,1'-CarbonyldiimidazoleHCID 113791591-(1,1-Dimethylethyl) 3,6-dihydro-1,3(2H)-pyridinedicarboxylate

Product 1

HCID 541197991-tert-Butyl 3-methyl 2,3-dihydropyridine-1,3(6H)-dicarboxylate

Sources & evidence

ORD record
ord-3613ce9385fe409cb1f016d1a49911b9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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