Hydrochloric Acid → 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-cyclohexyl-6-fluoro-3,4-dihydroisoquinoline-2(1H)-carboxamide

HRID 1542252Notes

Reaction equation

HRID 1542252 reaction equation
[CH:1]1([N:7]=[C:8]=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[ClH:35].[F:10][c:11]1[cH:12][c:13]2[c:18]([cH:19][c:20]1-[c:21]1[n:22][c:23]([NH2:34])[n:24][c:25]([N:27]3[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]3)[cH:26]1)[CH2:17][NH:16][CH2:15][CH2:14]2>>[CH:1]1([NH:7][C:8](=[O:9])[N:16]2[CH2:15][CH2:14][c:13]3[cH:12][c:11]([F:10])[c:20](-[c:21]4[n:22][c:23]([NH2:34])[n:24][c:25]([N:27]5[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]5)[cH:26]4)[cH:19][c:18]3[CH2:17]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 18502Cyclohexyl isocyanateHCID 594966484-(6-Fluoro-1,2,3,4-tetrahydroisoquinolin-7-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Product 1

HCID 497796447-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-cyclohexyl-6-fluoro-3,4-dihydroisoquinoline-2(1H)-carboxamide

Sources & evidence

ORD record
ord-fb22093026d84c70a90288837eafd948
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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