Carbonate Ion → Tert-butyl 3-(6-(6-chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)pyrrolidine-1-carboxylate
Reaction equation
[Br:20][c:21]1[c:22](=[O:29])[n:23]([CH3:28])[n:24][c:25]([Cl:27])[cH:26]1.[C:72](=[O:73])([O-:74])[O-:75].[Cs+:76].[Cs+:77].[NH2:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2)[cH:6][n:7]1.[O:104]=[C:105]([CH:106]=[CH:107][c:108]1[cH:109][cH:110][cH:111][cH:112][cH:113]1)[CH:114]=[CH:115][c:116]1[cH:117][cH:118][cH:119][cH:120][cH:121]1.[O:122]=[C:123]([CH:124]=[CH:125][c:126]1[cH:127][cH:128][cH:129][cH:130][cH:131]1)[CH:132]=[CH:133][c:134]1[cH:135][cH:136][cH:137][cH:138][cH:139]1.[O:78]1[CH2:79][CH2:80][O:81][CH2:82][CH2:83]1.[O:86]=[C:87]([CH:88]=[CH:89][c:90]1[cH:91][cH:92][cH:93][cH:94][cH:95]1)[CH:96]=[CH:97][c:98]1[cH:99][cH:100][cH:101][cH:102][cH:103]1.[Pd:84].[Pd:85].[c:30]1([P:31]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[c:38]2[c:39]3[c:63]([cH:64][cH:65][cH:66]2)[C:60]([CH3:61])([CH3:62])[c:42]2[c:41]([c:46]([P:47]([c:48]4[cH:49][cH:50][cH:51][cH:52][cH:53]4)[c:54]4[cH:55][cH:56][cH:57][cH:58][cH:59]4)[cH:45][cH:44][cH:43]2)[O:40]3)[cH:67][cH:68][cH:69][cH:70][cH:71]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2)[cH:6][n:7]1)[c:21]1[c:22](=[O:29])[n:23]([CH3:28])[n:24][c:25]([Cl:27])[cH:26]1Participants
9
Reactant 8
HCID 19660Carbonate Ion
HCID 23938Palladium2×
HCID 312751,4-Dioxane
HCID 95417Dibenzylidene acetone3×
HCID 104967Cesium cation2×
HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)
HCID 592164744-Bromo-6-chloro-2-methyl-2,3-dihydropyridazin-3-one
HCID 66742238Tert-butyl 3-(6-aminopyridin-3-yl)pyrrolidine-1-carboxylateProduct 1
Sources & evidence
- ORD record
- ord-b73a2cd6091f4b91befa8e58737596c6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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