Acetone → 1-(2-Methylbenzothiazol-5-yloxy)-3-piperazin-1-ylpropan-2-ol

HRID 1542327Notes

Reaction equation

HRID 1542327 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH:15]([CH2:16][O:17][c:18]2[cH:19][cH:20][c:21]3[c:22]([n:23][c:24]([CH3:26])[s:25]3)[cH:27]2)[OH:28])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[C:43](=[O:44])([O-:45])[O-:46].[CH2:29]([Cl:30])[Cl:31].[CH3:39][C:40](=[O:41])[CH3:42].[F:32][C:33]([F:34])([F:35])[C:36]([OH:37])=[O:38].[K+:47].[K+:48]>>[NH:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH:15]([CH2:16][O:17][c:18]2[cH:19][cH:20][c:21]3[c:22]([n:23][c:24]([CH3:26])[s:25]3)[cH:27]2)[OH:28])[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 180AcetoneHCID 813Potassium Cation2×HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 19660Carbonate IonHCID 219355284-[2-Hydroxy-3-(2-methylbenzothiazol-5-yloxy)propyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 219116911-(2-Methylbenzothiazol-5-yloxy)-3-piperazin-1-ylpropan-2-ol

Sources & evidence

ORD record
ord-0f6a8233ede04c339091d5ea9f7daf87
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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