Dichloromethane → 7-{2-[(2-methoxy-pyridin-4-ylmethyl)-amino]-benzoylamino}-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
Reaction equation
[B-:40]([F:41])([F:42])([F:43])[F:44].[C:20]([CH3:21])([CH3:22])([CH3:23])[O:24][C:25](=[O:26])[N:27]1[CH2:28][c:29]2[cH:30][c:31]([NH2:39])[cH:32][cH:33][c:34]2[C:35]([CH3:37])([CH3:38])[CH2:36]1.[CH3:1][O:2][c:3]1[n:4][cH:5][cH:6][c:7]([CH2:9][NH:10][c:11]2[c:12]([C:13](=[O:14])[OH:15])[cH:16][cH:17][cH:18][cH:19]2)[cH:8]1.[CH:62]([N:63]([CH2:64][CH3:65])[CH:66]([CH3:67])[CH3:68])([CH3:69])[CH3:70].[Cl:71][CH2:72][Cl:73].[n:45]1([O:46][C:47]([N:48]([CH3:49])[CH3:50])=[N+:51]([CH3:52])[CH3:53])[c:54]2[cH:55][cH:56][cH:57][cH:58][c:59]2[n:60][n:61]1>>[CH3:1][O:2][c:3]1[n:4][cH:5][cH:6][c:7]([CH2:9][NH:10][c:11]2[c:12]([C:13](=[O:15])[NH:39][c:31]3[cH:30][c:29]4[c:34]([cH:33][cH:32]3)[C:35]([CH3:37])([CH3:38])[CH2:36][N:27]([C:25]([O:24][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:26])[CH2:28]4)[cH:16][cH:17][cH:18][cH:19]2)[cH:8]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-c4da083a362d4a378fff4d0026276a73
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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