Acetate → Tert-butyl 2-(2',3-difluoro-2,4'-bipyridin-5-yl)acetate

HRID 1542499Notes

Reaction equation

HRID 1542499 reaction equation
[CH3:35][CH:36]([OH:37])[CH2:38][CH3:39].[CH3:40][CH2:41][O:42][C:43](=[O:44])[CH3:45].[Cl:1][c:2]1[c:3]([F:16])[cH:4][c:5]([CH2:8][C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[cH:6][n:7]1.[F:17][c:18]1[n:19][cH:20][cH:21][c:22]([B:24]([OH:25])[OH:26])[cH:23]1.[K+:32].[K+:33].[K+:34].[O-:47][C:48]([CH3:49])=[O:50].[O-:51][C:52]([CH3:53])=[O:54].[P:27]([O-:28])([O-:29])([O-:30])=[O:31].[Pd+2:46]>>[c:2]1(-[c:22]2[cH:21][cH:20][n:19][c:18]([F:17])[cH:23]2)[c:3]([F:16])[cH:4][c:5]([CH2:8][C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[cH:6][n:7]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 813Potassium Cation3×HCID 1061PhosphateHCID 6568(+-)-2-ButanolHCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27833962-Fluoropyridine-4-boronic acidHCID 58365072Tert-butyl 2-(6-chloro-5-fluoropyridin-3-yl)acetate

Product 1

HCID 58447733Tert-butyl 2-(2',3-difluoro-2,4'-bipyridin-5-yl)acetate

Sources & evidence

ORD record
ord-01781156bcde40e3b47203b979b6e09b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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