Chloride → 4-[2-(Acetylamino)-4-methyl-1,3-thiazol-5-yl]-5-bromothiophene-2-sulfonylchloride

HRID 1543363Notes

Reaction equation

HRID 1543363 reaction equation
[Br:1][c:2]1[s:3][cH:4][cH:5][c:6]1-[c:7]1[c:8]([CH3:16])[n:9][c:10]([NH:12][C:13]([CH3:14])=[O:15])[s:11]1.[Cl-:28].[Cl:17][S:18](=[O:19])(=[O:20])[OH:21].[Cl:22][P:23]([Cl:24])([Cl:25])([Cl:26])[Cl:27].[Cl:31][CH2:32][Cl:33].[P+:29]=[O:30]>>[Br:1][c:2]1[s:3][c:4]([S:18]([Cl:17])(=[O:19])=[O:20])[cH:5][c:6]1-[c:7]1[c:8]([CH3:16])[n:9][c:10]([NH:12][C:13]([CH3:14])=[O:15])[s:11]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 6344DichloromethaneHCID 24638Chlorosulfonic acidHCID 24819Phosphorus pentachlorideHCID 86652439N-[5-(2-Bromo-thiophen-3-yl)-4-methyl-thiazol-2-yl]-acetamideHCID 178526995HCID 178526995, compound

Product 1

HCID 866231464-[2-(Acetylamino)-4-methyl-1,3-thiazol-5-yl]-5-bromothiophene-2-sulfonylchloride

Sources & evidence

ORD record
ord-54fe4e86f90045ebb2eb71499eceb121
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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