Tetrahydrofuran → 2-[1-(3-cyano-2-methylphenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-N-(5-cyano-2-pyridinyl)-3-(2-hydroxyethoxy)propanamide

HRID 154397Notes

Reaction equation

HRID 154397 reaction equation
[C:19]([Si:20]([c:21]1[cH:22][cH:23][cH:60][cH:61][cH:62]1)([O:24][CH2:25][CH2:26][O:27][CH2:28][CH:29]([C:30](=[O:31])[NH:32][c:33]1[n:34][cH:35][c:36]([C:39]#[N:40])[cH:37][cH:38]1)[O:41][c:42]1[c:43]2[c:44]([n:45][cH:46][n:47]1)[n:48](-[c:51]1[c:52]([CH3:59])[c:53]([C:57]#[N:58])[cH:54][cH:55][cH:56]1)[n:49][cH:50]2)[c:63]1[cH:64][cH:65][cH:66][cH:67][cH:68]1)([CH3:69])([CH3:70])[CH3:71].[CH2:72]1[O:73][CH2:74][CH2:75][CH2:76]1.[CH3:2][CH2:3][CH2:4][CH2:5][N+:6]([CH2:7][CH2:8][CH2:9][CH3:10])([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:15][CH2:16][CH2:17][CH3:18].[F-:1]>>[OH:24][CH2:25][CH2:26][O:27][CH2:28][CH:29]([C:30](=[O:31])[NH:32][c:33]1[n:34][cH:35][c:36]([C:39]#[N:40])[cH:37][cH:38]1)[O:41][c:42]1[c:43]2[c:44]([n:45][cH:46][n:47]1)[n:48](-[c:51]1[c:52]([CH3:59])[c:53]([C:57]#[N:58])[cH:54][cH:55][cH:56]1)[n:49][cH:50]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 178428498HCID 178428498, compound

Product 1

HCID 765504262-[1-(3-cyano-2-methylphenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-N-(5-cyano-2-pyridinyl)-3-(2-hydroxyethoxy)propanamide

Sources & evidence

ORD record
ord-d452be014ebb4eceb7f5f2293fe5e2f1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…