Tetrahydrofuran → Benzyl 4-{4-[3-(2,5-difluorophenoxy)propoxy]phenyl}-3-[4-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

HRID 1544193Notes

Reaction equation

HRID 1544193 reaction equation
[CH3:63][CH2:64][CH2:65][CH2:66][N+:67]([CH2:68][CH2:69][CH2:70][CH3:71])([CH2:72][CH2:73][CH2:74][CH3:75])[CH2:76][CH2:77][CH2:78][CH3:79].[F-:62].[F:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([O:31][CH2:32][c:33]4[cH:34][cH:35][c:36]5[c:37]([cH:56]4)[N:38]([CH2:43][CH2:44][O:45][Si:46]([CH:47]([CH3:48])[CH3:49])([CH:50]([CH3:51])[CH3:52])[CH:53]([CH3:54])[CH3:55])[C:39](=[O:42])[CH2:40][O:41]5)[CH2:17][N:18]([C:21](=[O:22])[O:23][CH2:24][c:25]4[cH:26][cH:27][cH:28][cH:29][cH:30]4)[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:57][c:58]([F:61])[cH:59][cH:60]1.[O:80]1[CH2:81][CH2:82][CH2:83][CH2:84]1>>[F:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([O:31][CH2:32][c:33]4[cH:34][cH:35][c:36]5[c:37]([cH:56]4)[N:38]([CH2:43][CH2:44][OH:45])[C:39](=[O:42])[CH2:40][O:41]5)[CH2:17][N:18]([C:21](=[O:22])[O:23][CH2:24][c:25]4[cH:26][cH:27][cH:28][cH:29][cH:30]4)[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:57][c:58]([F:61])[cH:59][cH:60]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 68501828HCID 68501828, compound

Product 1

HCID 68505178Benzyl 4-{4-[3-(2,5-difluorophenoxy)propoxy]phenyl}-3-[4-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-bf18fddaafe74f0bb9547f4bb7919d8e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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