Ammonia → 5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH:15]([F:16])[F:17])[NH:9][C:10](=[O:14])[CH2:11][O:12][CH2:13]2)[cH:7]1.[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[Cl:21][CH2:22][Cl:23].[NH3:19].[OH2:20]>>[Br:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH:15]([F:16])[F:17])[N:9]=[C:10]([NH2:19])[CH2:11][O:12][CH2:13]2)[cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-cd99195f9a984b38b9df327c3d530bc3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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