Hydrochloric Acid → HCID 131720547, compound

HRID 1545Notes

Reaction equation

HRID 1545 reaction equation
[ClH:1].[OH:2][CH:3]([CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([OH:30])[CH:24]=1)[CH2:4][NH:5][CH:6]([CH3:20])[CH2:7][C:8]1[CH:19]=[CH:18][C:11]([O:12][CH2:13][C:14]([O:16]C)=[O:15])=[CH:10][CH:9]=1.Cl>O>[ClH:1].[OH:30][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][C:26]=1[OH:29])[O:22][CH2:21][CH:3]([OH:2])[CH2:4][NH:5][CH:6]([CH3:20])[CH2:7][C:8]1[CH:19]=[CH:18][C:11]([O:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131720548HCID 131720548, compound

Product 1

HCID 131720547HCID 131720547, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A solution of (SR)-4-{2-[2-hydroxy-3-(3,4-dihydroxyphenoxy)propylamino]propyl}phenoxyacetic acid, methyl ester, hydrochloride (78 mg, 0.17 mMol) in water (2 ml) containing hydrochloric acid (1M, 0.5 ml, 0.51 mMol) was heated at 100° C. under argon for 3 hours. After cooling to room temperature the solution was freeze dried giving the title compound as a colourless solid.

Workup

  1. temperatureAfter cooling to room temperature the solution
  2. customdried

Sources & evidence

ORD record
ord-bcd59e6d31334fa7a06760faa96f245d
Source dataset
uspto-grants-1998_03
Patent number
US05726165

Reaction notes

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