Methanol → [2-(2-Amino-4-fluorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-7-yl]methanol

HRID 1545887Notes

Reaction equation

HRID 1545887 reaction equation
[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:25][OH:26].[H:23][H:24].[OH:1][CH2:2][CH:3]1[CH2:4][CH2:5][CH:6]2[N:7]([CH2:8][CH2:9][N:10]([c:12]3[c:13]([N+:19]([O-:20])=[O:21])[cH:14][c:15]([F:18])[cH:16][cH:17]3)[CH2:11]2)[CH2:22]1>>[OH:1][CH2:2][CH:3]1[CH2:4][CH2:5][CH:6]2[N:7]([CH2:8][CH2:9][N:10]([c:12]3[c:13]([NH2:19])[cH:14][c:15]([F:18])[cH:16][cH:17]3)[CH2:11]2)[CH2:22]1

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 178418361HCID 178418361, compoundHCID 178526734[2-(4-fluoro-2-nitrophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-7-yl]methanol

Product 1

HCID 21997239[2-(2-Amino-4-fluorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-7-yl]methanol

Sources & evidence

ORD record
ord-9dfee87791a84bf5af98f87158ddcaa4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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