Water → 8-[tert-butyl(dimethyl)silyl]oxy-2-methyl-9-phenyl-6,8,9,10-tetrahydro-5H-imidazo[1,2-h][1,7]naphthyridin-7-one

HRID 1546461Notes

Reaction equation

HRID 1546461 reaction equation
[CH3:1][c:2]1[n:3][c:4]2[n:5]([cH:11]1)[CH2:6][CH2:7][CH2:8][C:9]2=[O:10].[NH2:12][CH:13]([CH:14]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[O:20][Si:21]([CH3:22])([CH3:23])[C:24]([CH3:25])([CH3:26])[CH3:27])[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[OH2:34].[OH2:46].[c:35]1([CH3:36])[cH:37][cH:38][c:39]([S:40]([OH:41])(=[O:42])=[O:43])[cH:44][cH:45]1>>[CH3:1][c:2]1[n:3][c:4]2[n:5]([cH:11]1)[CH2:6][CH2:7][C:8]1=[C:9]2[NH:12][CH:13]([c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[CH:14]([O:20][Si:21]([CH3:22])([CH3:23])[C:24]([CH3:25])([CH3:26])[CH3:27])[C:15]1=[O:16]

Participants

5

Reactant 4

HCID 962Water2×HCID 6101p-Toluenesulfonic acidHCID 120824682-Methyl-6,7-dihydroimidazo[1,2-a]pyridin-8(5H)-oneHCID 77632775Ethyl 3-amino-2-[tert-butyl(dimethyl)silyl]oxy-3-phenylpropanoate

Product 1

HCID 218739208-[tert-butyl(dimethyl)silyl]oxy-2-methyl-9-phenyl-6,8,9,10-tetrahydro-5H-imidazo[1,2-h][1,7]naphthyridin-7-one

Sources & evidence

ORD record
ord-24b5757c91b546408af63264bf4d9e54
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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