Tetrahydrofuran → tert-butyl 4-(1-(4-chlorophenyl)-3-hydroxypropylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

HRID 1546606Notizen

Reaktionsgleichung

[Al+3:2].[C:7]([CH3:8])([CH3:9])([CH3:10])[O:11][C:12](=[O:13])[NH:14][C:15]1([C:30](=[O:31])[NH:32][CH:33]([CH2:34][C:35](=[O:36])[O:37][CH3:38])[c:39]2[cH:40][cH:41][c:42]([Cl:45])[cH:43][cH:44]2)[CH2:16][CH2:17][N:18]([c:21]2[c:22]3[c:23]([n:24][cH:25][n:26]2)[nH:27][cH:28][cH:29]3)[CH2:19][CH2:20]1.[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3]>>[C:7]([CH3:8])([CH3:9])([CH3:10])[O:11][C:12](=[O:13])[NH:14][C:15]1([C:30](=[O:31])[NH:32][CH:33]([CH2:34][CH2:35][OH:36])[c:39]2[cH:40][cH:41][c:42]([Cl:45])[cH:43][cH:44]2)[CH2:16][CH2:17][N:18]([c:21]2[c:22]3[c:23]([n:24][cH:25][n:26]2)[nH:27][cH:28][cH:29]3)[CH2:19][CH2:20]1

Komponenten

Edukt 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 57750359methyl 3-(4-(tert-butoxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)-3-(4-chlorophenyl)propanoate

Produkt 1

HCID 57750387tert-butyl 4-(1-(4-chlorophenyl)-3-hydroxypropylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

Quellen und Nachweise

ORD-Eintrag: ord-3f68b4649200496abddf35da3f84a135
Quelldatensatz: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Notizen zur Reaktion

Wird geladen…