Toluene → 4-Chloro-7-methoxy-8-(2-morpholin-4-yl ethoxy)benzo[g]quinoline-3-carbonitrile

HRID 154678Notes

Reaction equation

HRID 154678 reaction equation
[CH3:1][O:2][c:3]1[c:4]([O:20][CH2:21][CH2:22][N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[cH:5][c:6]2[c:7]([cH:8][c:9]3[c:10](=[O:18])[c:11]([C:16]#[N:17])[cH:12][nH:13][c:14]3[cH:15]2)[cH:19]1.[CH3:34][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1.[P:29]([Cl:30])([Cl:31])([Cl:32])=[O:33]>>[CH3:1][O:2][c:3]1[c:4]([O:20][CH2:21][CH2:22][N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[cH:5][c:6]2[c:7]([cH:8][c:9]3[c:10]([Cl:31])[c:11]([C:16]#[N:17])[cH:12][n:13][c:14]3[cH:15]2)[cH:19]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 24813Phosphorus oxychlorideHCID 120627417-Methoxy-8-(2-morpholin-4-yl-ethoxy)4-oxo-1,4-dihydrobenzo[g]quinoline-3-carbonitrile

Product 1

HCID 120627424-Chloro-7-methoxy-8-(2-morpholin-4-yl ethoxy)benzo[g]quinoline-3-carbonitrile

Sources & evidence

ORD record
ord-dcc05ac4fb0146deb1d31df5195ebd14
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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