Tetrahydrofuran → Tert-butyl 4-[cyano(phenyl)methyl]-4-hydroxypiperidine-1-carboxylate

HRID 1546922Notes

Reaction equation

HRID 1546922 reaction equation
[C:15](=[O:16])([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[N:22]1[CH2:23][CH2:24][C:25](=[O:28])[CH2:26][CH2:27]1.[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[C:8]#[N:9].[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:10][CH2:11][CH2:12][CH2:13][Li:14]>>[CH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([C:8]#[N:9])[C:25]1([OH:28])[CH2:24][CH2:23][N:22]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:27][CH2:26]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8794PhenylacetonitrileHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 58415929Tert-butyl 4-[cyano(phenyl)methyl]-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-284b8b55b21b450cad12e7eb2db5bb03
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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