HRID1547

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCCCOP(=O)(CCCOCc1ccccc1)COc1ccc(CC(C)NCC(O)COc2ccc(O)c(CO)c2)cc1

HCID131720551

未命名化合物

PRODUCTS

生成物

结构：CC(Cc1ccc(OCP(=O)(O)CCCOCc2ccccc2)cc1)NCC(O)COc1ccc(O)c(CO)c1.Cl

HCID131720550

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (SR)-4-{2-[2-hydroxy-3-(4-hydroxy-3-hydroxymethylphenoxy)propylamino]propyl}phenoxymethyl(3-benzyloxypropyl)phosphinic acid, n-butyl ester according to a modification of the procedure described in Example 5. Acidification to pH 3.5 with 1M hydrochloric acid followed by C18 reverse phase chromatography, eluting with water-methanol (30%) and freeze drying of the resultant foam gave the title compound as a solid.

WORKUP

后处理

washeluting with water-methanol (30%)
customfreeze drying of the resultant foam

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-53f0eba6f5424c5d8afd83daf49ced93
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05726165
来源说明: uspto-grants-1998_03

反应 SMILES

[OH:1][CH:2]([CH2:34][O:35][C:36]1[CH:41]=[CH:40][C:39]([OH:42])=[C:38]([CH2:43][OH:44])[CH:37]=1)[CH2:3][NH:4][CH:5]([CH3:33])[CH2:6][C:7]1[CH:32]=[CH:31][C:10]([O:11][CH2:12][P:13]([CH2:20][CH2:21][CH2:22][O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:19])[O:14]CCCC)=[CH:9][CH:8]=1.[ClH:45]>>[ClH:45].[OH:1][CH:2]([CH2:34][O:35][C:36]1[CH:41]=[CH:40][C:39]([OH:42])=[C:38]([CH2:43][OH:44])[CH:37]=1)[CH2:3][NH:4][CH:5]([CH3:33])[CH2:6][C:7]1[CH:32]=[CH:31][C:10]([O:11][CH2:12][P:13]([CH2:20][CH2:21][CH2:22][O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:14])[OH:19])=[CH:9][CH:8]=1