Methane → 2,4-Difluoro-3-(2-morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)phenol

HRID 1547717Notes

Reaction equation

HRID 1547717 reaction equation
[C:40].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([F:37])[c:11](-[c:16]2[c:17]3[c:18]([n:19][c:20]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)[n:21]2)[N:28]([c:31]2[cH:32][cH:33][n:34][cH:35][cH:36]2)[CH2:29][CH2:30]3)[c:12]([F:15])[cH:13][cH:14]1.[CH3:38][OH:39].[Pd:41]>>[OH:8][c:9]1[c:10]([F:37])[c:11](-[c:16]2[c:17]3[c:18]([n:19][c:20]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)[n:21]2)[N:28]([c:31]2[cH:32][cH:33][n:34][cH:35][cH:36]2)[CH2:29][CH2:30]3)[c:12]([F:15])[cH:13][cH:14]1

Participants

5

Reactant 4

HCID 297MethaneHCID 887MethanolHCID 23938PalladiumHCID 248902744-(3-Benzyloxy-2,6-difluoro-phenyl)-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 248904422,4-Difluoro-3-(2-morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)phenol

Sources & evidence

ORD record
ord-ba4181225d594adb9cec84b8e7edb5c8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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