Dimethyl Sulfoxide → 1-(4-chlorophenyl)-2-oxo-7-(trifluoromethyl)-2,3-dihydro-1H-benzimidazole-5-carbonitrile

HRID 1547946Notes

Reaction equation

HRID 1547946 reaction equation
[CH3:33][S:34](=[O:35])[CH3:36].[Cu:23][C:24]#[N:25].[N:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32].[NH2:1][c:2]1[cH:3][c:4]2[c:5]([n:6](-[c:10]3[cH:11][cH:12][c:13]([Cl:16])[cH:14][cH:15]3)[c:7](=[O:9])[nH:8]2)[c:17]([C:19]([F:20])([F:21])[F:22])[cH:18]1>>[c:2]1([C:24]#[N:25])[cH:3][c:4]2[c:5]([n:6](-[c:10]3[cH:11][cH:12][c:13]([Cl:16])[cH:14][cH:15]3)[c:7](=[O:9])[nH:8]2)[c:17]([C:19]([F:20])([F:21])[F:22])[cH:18]1

Participants

5

Reactant 4

HCID 679Dimethyl SulfoxideHCID 10906Tert-Butyl nitriteHCID 223273675-amino-1-(4-chlorophenyl)-7-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-oneHCID 178418546HCID 178418546, compound

Product 1

HCID 223273651-(4-chlorophenyl)-2-oxo-7-(trifluoromethyl)-2,3-dihydro-1H-benzimidazole-5-carbonitrile

Sources & evidence

ORD record
ord-93804b0f3ca5439881859fe37eb51b27
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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