Pyridine → N-{5-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-methyl-1H-imidazole-4-sulfonamide

HRID 1547982Notes

Reaction equation

HRID 1547982 reaction equation
[CH3:30][n:31]1[cH:32][n:33][c:34]([S:36](=[O:37])(=[O:38])[Cl:39])[cH:35]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:23])[c:20]([NH2:22])[cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1.[O:40]=[CH:41][N:42]([CH3:43])[CH3:44].[cH:24]1[cH:25][cH:26][n:27][cH:28][cH:29]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:23])[c:20]([NH:22][S:36]([c:34]4[n:33][cH:32][n:31]([CH3:30])[cH:35]4)(=[O:37])=[O:38])[cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6228DimethylformamideHCID 27368871-methyl-1H-imidazole-4-sulfonyl chlorideHCID 579897855-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluoroaniline

Product 1

HCID 86636583N-{5-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-methyl-1H-imidazole-4-sulfonamide

Sources & evidence

ORD record
ord-f55f1163b2fe40cdbb0b7d8810d2ae96
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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