Dichloromethane → Trifluoroacetic acid

HRID 1548077Notes

Reaction equation

HRID 1548077 reaction equation
[Cl:34][CH2:35][Cl:36].[F:27][C:28]([C:29](=[O:30])[OH:31])([F:32])[F:33].[O:1]=[C:2]1[NH:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[C:10]12[CH2:11][c:12]1[c:13]([n:14][c:15]([NH:18][C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[cH:16][cH:17]1)[CH2:26]2>>[F:27][C:28]([C:29](=[O:30])[OH:31])([F:32])[F:33].[O:1]=[C:2]1[NH:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[C:10]12[CH2:11][c:12]1[c:13]([n:14][c:15]([NH2:18])[cH:16][cH:17]1)[CH2:26]2

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 86616405(+/-)-tert-Butyl (2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2-yl)carbamate

Product 2

HCID 6422Trifluoroacetic acidHCID 57974056(+/-)-2-Amino-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Sources & evidence

ORD record
ord-09a8960d8ccc42a7997ad934339f5595
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…