Chloride → 4-(3,5-Difluoro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][c:16]([F:22])[c:17]([F:21])[cH:18][c:19]2[F:20])[CH2:12][CH2:13]1.[C:44]1([Ti+2:45][C:46]2=[CH:50][CH:49]=[CH:48][CH2:47]2)=[CH:54][CH:53]=[CH:52][CH2:51]1.[CH3:24][O:25][CH2:26][CH2:27][O:28][AlH2-:29][O:30][CH2:31][CH2:32][O:33][CH3:34].[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[Cl-:42].[Cl-:43].[Na+:23]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([F:21])[cH:18][c:19]2[F:20])[CH2:12][CH2:13]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-e61eac8a7b34488ca098fa4f025e275e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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