Dichloromethane → 4-(2,4-Difluorophenyl)-piperidine-4-carbonitrile

HRID 1548507Notes

Reaction equation

HRID 1548507 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][cH:19]2)([C:22]#[N:23])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:24][CH2:25][Cl:26].[OH:27][C:28]([C:29]([F:30])([F:31])[F:32])=[O:33]>>[NH:8]1[CH2:9][CH2:10][C:11]([c:14]2[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][cH:19]2)([C:22]#[N:23])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 18353388tert-Butyl 4-cyano-4-(2,4-difluorophenyl)piperidine-1-carboxylate

Product 1

HCID 105132084-(2,4-Difluorophenyl)-piperidine-4-carbonitrile

Sources & evidence

ORD record
ord-65797832d29d4670a8b0d3c0a0b69d28
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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