Hydrochloric Acid → HCID 67683417, compound

HRID 1549Notes

Reaction equation

HRID 1549 reaction equation
[OH:1][CH:2]([CH2:28][O:29][C:30]1[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=1)[CH2:3][NH:4][CH2:5][CH2:6][CH:7]([CH2:26][CH3:27])[CH2:8][CH2:9][CH2:10][P@:11]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)(=[O:17])[O:12]CCCC.Cl>>[OH:1][CH:2]([CH2:28][O:29][C:30]1[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=1)[CH2:3][NH:4][CH2:5][CH2:6][C@@H:7]([CH2:26][CH3:27])[CH2:8][CH2:9][CH2:10][P:11]([CH2:18][O:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)(=[O:12])[OH:17]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86752205(S)-4-{2-[2-hydroxy-3-(4-hydroxyphenoxy)propylamino]ethyl}phenoxymethyl-n-hexyl phosphinic acid, n-butyl ester

Product 1

HCID 67683417HCID 67683417, compound

Procedure

The title compound was prepared from (S)-4-{2-[2-hydroxy-3-(4-hydroxyphenoxy)propylamino]ethyl}phenoxymethyl-n-hexyl phosphinic acid, n-butyl ester according a modification of the procedure described in Example 25. Acidification to pH 6 with 1M hydrochloric acid followed by C18 reverse phase chromatography and freeze drying gave the title compound as a solid.

Workup

  1. customdrying

Sources & evidence

ORD record
ord-f306d8cee34644e195747dc14d730ec8
Source dataset
uspto-grants-1998_03
Patent number
US05726165

Reaction notes

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