Dichloromethane → 6-Amino-1-(2,3-difluorobenzyl)-4-(2,2,2-trifluoroethyl)-1,4-diazepan-5-one
Reaction equation
[Cl:38][CH2:39][Cl:40].[F:8][c:9]1[c:10]([CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH2:28][C:29]([F:30])([F:31])[F:32])[C:16](=[O:27])[CH:17]([NH:19][C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18]2)[cH:33][cH:34][cH:35][c:36]1[F:37].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[F:8][c:9]1[c:10]([CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH2:28][C:29]([F:30])([F:31])[F:32])[C:16](=[O:27])[CH:17]([NH2:19])[CH2:18]2)[cH:33][cH:34][cH:35][c:36]1[F:37]Participants
4
Sources & evidence
- ORD record
- ord-839a785103834cb488fb29b28e9264d1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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