Methanol → tert-Butyl 6-fluoro-4-oxo-3,4-dihydro-1'H-spiro[1-benzopyran-2,4'-piperidine]-1'-carboxylate

HRID 1549838Notes

Reaction equation

HRID 1549838 reaction equation
[CH2:15]1[CH2:16][NH:17][CH2:18][CH2:19]1.[CH3:31][OH:32].[F:20][c:21]1[cH:22][cH:23][c:24]([OH:30])[c:25]([C:27]([CH3:28])=[O:29])[cH:26]1.[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[O:1]1[C:2]2([CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]2)[CH2:28][C:27](=[O:29])[c:25]2[c:24]1[cH:23][cH:22][c:21]([F:20])[cH:26]2

Participants

5

Reactant 4

HCID 887MethanolHCID 31268PyrrolidineHCID 959922-Acetyl-4-fluorophenolHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 11759463tert-Butyl 6-fluoro-4-oxo-3,4-dihydro-1'H-spiro[1-benzopyran-2,4'-piperidine]-1'-carboxylate

Sources & evidence

ORD record
ord-f0dc1daa3c174203940a5f3b11fe177e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…