HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67683445, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (SR)-4-{2-[2-hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)propylamino]propyl}phenoxymethylbenzylphosphinic acid, n-butyl ester | HCID 86752206 | — |
| Product | HCID 67683445 | HCID 67683445 | — |
Reaction Steps
The title compound was prepared from (SR)-4-{2-[2-hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)propylamino]propyl}phenoxymethylbenzylphosphinic acid, n-butyl ester according to the method described in Example 5 followed by acidification to pH 3.5 with 1M hydrochloric acid, as a solid (mp 180°-183° C.) following chromatography on C18 reverse phase silica-gel, eluting with 40% methanol in water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05726165 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-7dcfc77b6fae44dabea5f16d26269c62 |
| Source note | uspto-grants-1998_03 |